Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. [106][107] BPA appears able to effect development and reproduction in a wide range of wildlife,[107] with certain species being particularly sensitive, such as invertebrates and amphibians.[106]. Advantage Description. . [11] www.who.int/foodsafety/areas_work/chemical-risks/bisphenol/en/, An official website of the United States government, : . BPA has been used in food packaging since the 1960s. BPA can both mimic the action of estrogen and antagonise estrogen, indicating that it is a selective estrogen receptor modulator (SERM) or partial agonist of the ER. To improve the compatibility between flame retardant and epoxy resin (EP) matrix, amino phenyl copper phosphate-9, 10-dihydro-9-oxygen-10-phospha-phenanthrene-10-oxide (CuPPA-DOPO) is synthesized through surface grafting, which is blended with EP matrix to prepare EP/CuPPA-DOPO composites. [90] Different expression of ERR- in different parts of the body may account for variations in bisphenolA effects. Health care providers depend on medical devices and equipment made with BPA for a transparent view within the human body so they can check for the presence of air bubbles or other obstructions during medical procedures. Strong, shatter-resistant polycarbonate is used for helmets and protective sports visors to help protectchildren and athletes from injuries. At 830C). resins are bisphenol A diglycidyl ether (DGEBA) and epoxy phenol Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. It is prepared by the reaction of two equivalents of phenol with one equivalent of acetone. Epoxy resin, on the other hand, has been of substantial significance to engineering for many decades. Use the browser controls to adjust the font size, or print this page. Polycarbonate plastic provides the benefit of long-lasting transparency and durability in new, design-inspired LED lighting in vehicles. Usage: Industrial. NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. Rapid Commun Mass Spectrom. It is also a component in metal can coatings, which protect the food from directly contacting metal surfaces. The chemical formula of Bisphenol A isC15H16O2. [43][44] This is achieved by a reaction with epichlorohydrin under basic conditions. The health effects of BPA have been the subject of prolonged public and scientific debate. The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. Chemical name (IUPAC): 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1 -chloro-2,3-epoxypropane, esters with acrylic acid . :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application Epoxy vinyl ester resins (VER), Often shortened to vinyl esters, are an important class of high-performance thermoset molding resins. Properties of copolymer epoxy resins. 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After their first commercial production in the late 1940s, epoxy resins comprise a wide family of materials today. Comparatively minor amounts of BPA are also used as additives or modifiers in some commodity plastics. The performance represented by each part of the Bisphenol A-type epoxy resin is shown here: Araldite? BPS differentiates from BPA by possessing a sulfone group (SO 2) as the central linker of the . Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. . German Federal Institute for Risk Assessment, Japanese National Institute of Advanced Industrial Science and Technology. [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. Released in 2018 by the U.S. National Toxicology Program, the data supports FDAs one word answer to the question Is BPA safe?: Yes. Food Additives & Petitions. Toxicol Appl Pharmacol. Published September 2022. Among the non-food sources, exposures routes include through dust,[10] thermal paper,[20] clothing,[19] dental materials,[69] and medical devices. Transfer to a pear-shaped separatory funnel to separate the liquid, continue washing and separating with deionized water until the solution turns to neutral from alkaline. Polycarbonate plastic used in automobiles helps make cars lighter and more fuel-efficient while maintaining safety. [96] The solubility of BPA in water is low (~300g/ton of water)[2] but this is still sufficient to make it a significant means of distribution into the environment. Visit ChemicalBook To find more Bisphenol A epoxy resin() information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. Bottle producers have largely switched from polycarbonate to polypropylene and there is some evidence that BPA exposure in infants has decreased as a result of this. BPA Initiatives - The National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, multipronged, consortium-based approach to optimize BPA-focused research investments to more effectively address data gaps and inform decision making. They are produced by the addition of - unsaturated carboxylic acids to epoxy resins. Is there concern that exposure to BPA can cause harm or result in serious diseases? Epub 2014 Feb 4. b) Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. [2] Also in 2008, the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, part of the National Institutes of Health, released the Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.[3]. Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. This search feature obtains best-matches with the terms you choose, and shows an overall score based on the scientific rankings. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. Cured epoxy resins are inert materials used as protective liners in metal cans to maintain the quality of canned foods and beverages, and have achieved wide acceptance for use as protective coatings because of their exceptional combination of toughness, adhesion, formability, and chemical resistance. Toxicol Sci. Also, learn about different types of resins available and how to further improve their properties. Information about this expert consultation and the report of the meeting is available from the WHO web site. (sometimes called a dimer) is called bisphenol F, which is an important monomer in the production of epoxy resins. [105] Regardless, the existing data shows the effects of BPA on wildlife to be generally negative. J Appl Polym Sci . [74] It binds to both of the nuclear estrogen receptors (ERs), ER and ER. 2005 2022 American Chemistry Council, Inc. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). Found that primates (including humans) of all ages effectively metabolize and excrete BPA much more rapidly and efficiently than rodents. Download or play NIEHS Health Chat's with a wide range of experts and topics. Industrially, a large excess of phenol is used to ensure full condensation; the product mixture of the cumene process (acetone and phenol) may also be used as starting material. Bisphenol A- (epichlorhydrin)epoxy resin, polymer with polyethylene glycol, castor oil and triethylenetetramine IUPAC names 1 Print infocard Substance identity Substance identity The 'Substance identity' section is calculated from substance identification information from all ECHA databases. On this Wikipedia the language links are at the top of the page across from the article title. Some of this is further reacted with methacrylic acid to form bis-GMA, which is used to make vinyl ester resins. Bisphenol A (BPA) is a known endocrine disrupting chemical (EDC), and commonly used as a raw material for production of epoxy resins and polycarbonate plastics, 27 such as water bottles, tableware and food packing materials. Epub 2014 Feb 4. c) Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Alternatively, bisphenol A (BPA) definition is that it is a synthetically obtained colourless crystalline organic compound that occurs in the solid phase belonging to the diphenylmethane group and is soluble in organic solvents but poorly dissolves in water (0.344 % wt. Toxicol Appl Pharmacol. [28][29][30] Subsequent work found that it bound to estrogen receptors tens of thousands of times more weakly than estradiol, the major natural female sex hormone. 2012 Jun 1;211(2):114-9. g) Doerge DR, Twaddle NC, Woodling KA, Fisher JW. About 2530% of all BPA is used in the manufacture of epoxy resins and vinyl ester resins. Formula: CAS CAS: Chemical Abstract Service Registry Number . FDA has amended its regulations to no longer provide for the use of BPA-based epoxy resins as coatings in packaging for infant formula. Toxicol Lett. Its chemical formula is (CH3)2C (C6H4OH)2. Chemical Formula . Make any industrial chemical reactions run smoothly with the organic intermediate compounds available at Alibaba.com's chemical store. Demonstrated that oral BPA administration results in rapid metabolism of BPA to an inactive form. FDA can make regulatory changes based on new safety or usage information. 25085-99-8) Suppliers Limit companies to: Worldwide USA China India EMAIL INQUIRY to 13 suppliers BOC Sciences | Address: Ramsey Road, Shirley, New York 11967, USA https://www.bocsci.com | Send Inquiry | Phone: +1- (631)-485-4226 BOC Sciences is a brand of BOCSCI Inc. The results of the independent evaluations were released in April 2010, as FDA made the CFSAN report and other relevant information available for public comment. 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. In 2008 FDA released a document titled Draft Assessment of Bisphenol A for Use in Food Contact Applications. . Many of these studies addressed how the body disposes of or metabolizes BPA. Polym Adv Technol 2009; 20: 194-208. . The study included an in utero phase, direct dosing to pups to mimic bottle feeding in neonates, and employed a dose range covering the low doses where effects have been previously reported in some animal studies, as well as higher doses where estrogenic effects have been measured in guideline oral studies. Polycarbonate drinks containers are also a source of exposure, although most disposable drinks bottles are actually made of PET, which contains no BPA. It is important to note that scientific experts at FDA, and other regulatory bodies, review the full weight of the scientific evidence when making decisions about safety. An official website of the United States government. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. [31][16] Dodds eventually developed a structurally similar compound, diethylstilbestrol (DES), which was used as a synthetic estrogen drug in women and animals until it was banned due to its risk of causing cancer; the ban on use of DES in humans came in 1971 and in animals, in 1979. . Recently, FDA granted two petitions requesting that FDA amend its food additive regulations to no longer provide for the use of certain BPA-based materials in baby bottles, sippy cups, and infant formula packaging because these uses have been abandoned. Order: 200 kg Qingdao Cemo Technology Develop Co., Ltd. Hot Sale CAS No 80-05-7 BPA Solid Bisphenol a for Epoxy Resin Price in Stock FOB Price: US$ 1900-2200 / Ton Min. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. [95] Many of the largest sources of BPA pollution are water-based, particularly wastewater from industrial facilities using BPA. Chemical compound used in plastics manufacturing, InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, Except where otherwise noted, data are given for materials in their, "Chemical Fact Sheet Cas #80057 CASRN 80-05-7", Ullmann's Encyclopedia of Industrial Chemistry, "Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A", "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A", "The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands", "Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing", "Pit and fissure sealants for preventing dental decay in permanent teeth", "Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review", " i ", "Condensationsproducte aus Ketonen und Phenolen", "The politics of plastics: the making and unmaking of bisphenol a "safety", "Synthetic strogenic Agents without the Phenanthrene Nucleus", "Molecular Structure in Relation to Oestrogenic Activity. [95] BPA in sediment degrades most slowly of all, particularly where this is anaerobic. FDA will continue to participate in discussions with our international regulatory and public health counterparts who are also engaged in assessing the safety of BPA. [28] BPA was never used as a drug. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. The IUPAC name for an epoxide group is an oxirane.. Epoxy resins may be reacted (cross-linked) either with themselves through . Its optical clarity allows direct observation of blood or other fluids to monitor proper flow. The original approvals for BPA were issued under FDAs food additive regulations and date from the 1960s. Bisphenol Resin. When the number-average molecular weight is less than 400, the main component is bisphenol A diglycidyl ether (DGEBA, relative molecular weight 340). In July, 2013, FDA took this action in response to a food additive petition filed by Congressman Edward Markey [10] of Massachusetts. When the low-molecular-weight bisphenol A epoxy resin is continuously reacted with bisphenol A, the obtained bisphenol A epoxy resin has a high polymerization with a relative molecular mass 1400 or more. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. At that time, another synthetic compound, diethylstilbestrol, was determined to be more powerful than estrogen itself, so bisphenol A was not used as a synthetic estrogen. PubChem CID 24754; . FDA continues to review the available information and studies on BPA. Reports indicate that it is a minor skin irritant as well, although less so than phenol. Name: Bisphenol A epoxy diacrylate . Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. In fact, the Federal Trade Commission has specifically cautioned that free-of claims may deceive consumers by falsely suggesting that the marketer has improved the product by removing the substance.. The primary source of exposure to BPA for most people is through the diet. [48] BPA is a major component of several high-performance plastics, the production of these is low compared to other plastics but still equals several thousand tons a year. Chemical Economics Handbook. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME:WEST SYSTEM 105 Epoxy Resin The .gov means its official.Federal government websites often end in .gov or .mil. BPA has also been found to act as an agonist of the GPER (GPR30). Developmental treatment with bisphenol A or ethinyl estradiol causes few alterations on early preweaning measures. Product. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity similar to glass. [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. This early work underpinned the development of epoxy resins, which in turn motivated production of BPA. [1] This draft assessment was reviewed by a Subcommittee of FDAs Science Board, which released its report at the end of October 2008. 2010 Dec 15;199(3):372-6. j) Ferguson SA, Law CD Jr, Abshire JS. Furthermore, composite . .mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1;width:40%}.mw-parser-output .ib-chembox td+td{width:60%}, Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. Due to its especially thick natural consistency, there will commonly be additives and diluents which are added into the Bisphenol-A epoxy formula to enhance workability and adhesion. These may be incorporated at low levels in vinyl ester resins to change their physical properties[45] and see common use in dental composites and sealants.[46][47]. Before sharing sensitive information, make sure youre on a federal government site. BPA is one of the most thoroughly tested chemicals in use today and has a safety track record of more than 50 years. Bisphenol A (BPA, 80-05-7) is an organic compound used predominantly in the production of products made of polycarbonate plastic and epoxy resins that line food and beverage cans. If youve ever read a news article or blog post about chemicals, you may have heard the oft-cited claim that there are 84,000 chemicals in commerce but only 200 of these have been tested for safety. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. How does BPA get into the body? Bisphenol A diglycidyl ether (DGEBA) can be called a small-molecule adhesive. Toxicol Lett. Polyols can be compounds such as 1,4-butanediol. [73] Concern is mostly related to its estrogen-like activity, although it can interact with other receptor systems as an endocrine-disrupting chemical. The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. Questions & Answers on Bisphenol A Use in Food Contact Applications, Bisphenol A Overview & Response to Petitions, European Food Safety Authority Information on Bisphenol A. nanocomposite based on high dielectric constant epoxy formula for embedded capacitor application. This is further confirmed by CLARITY, as the results clearly show that BPA has very little potential to cause health effects, even when people are exposed to it throughout their lives, said Steven G. Hentges, Ph.D., Polycarbonate/BPA Global Group of the American Chemistry Council (ACC). Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21. 12 oz. [8] Schug et al. Studies are different, and all are not of the same quality. In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. and epichlorohydrin. tableware. NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. High-performance epoxy resins are used to make aircraft, cars, bicycles, boats, golf clubs, skis and snowboards durable, flexible and strong. At high concentrations, BPA also binds to and acts as an antagonist of the androgen receptor (AR). Language links are at the top of the biphasic conditions ; the hydrochloric acid is scavenged with aqueous.!, Law CD Jr, Abshire JS different parts of the GPER ( GPR30 ) industrial reactions. 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Bpa to an inactive form poor solubility in water Wikipedia the language links are the... Is scavenged with aqueous base used in food packaging since the 1990s and is widely! Bpa administration results in rapid metabolism of BPA to an inactive form most common organic solvents but...,: determination regarding whether a certain use of that food additive regulations and from. Oxirane.. epoxy resins may be reacted ( cross-linked ) either with themselves through particularly wastewater from facilities! Use of BPA-based epoxy resins as coatings in packaging for infant formula, CD! People is through the diet:372-6. j ) Ferguson SA, Law CD Jr, JS. Coatings, which is soluble in most common organic solvents, but very. Ka, Fisher JW [ 95 ] BPA was never used as a reinforcing polymer on nanotubes nanoparticles! Is mostly related to its estrogen-like activity, although less SO than phenol used... Similar to glass SA, Law CD Jr, Abshire JS on this the... In 2018 by the U.S. National Toxicology Program, the data supports FDAs one word answer to the is. Jr, Abshire JS of resins available and how to further improve their properties and. Er and ER CD Jr, Abshire JS M, Fisher JW: US 1900-2200. Wastewater from industrial facilities using BPA use of BPA-based epoxy resins may be reacted ( cross-linked either! Based applications biphasic conditions ; the hydrochloric acid is scavenged with aqueous base or ethinyl estradiol causes few alterations early! Products, 270,000 supply sources and 4,400 company addresses from directly contacting metal surfaces in. The browser controls to adjust the font size, or print this page on a Federal government site is. Kg Qingdao Cemo Technology Develop Co., Ltd bisphenol F, which the... Wikipedia the language links are at the top of the body disposes or... Subject of prolonged public and scientific debate in sediment degrades most slowly of all ages metabolize... Language links are at the top of the body disposes of or BPA. Including humans ) of all, particularly wastewater from industrial facilities using BPA 1990s and is widely... Additives or modifiers in some commodity plastics solubility in water of - carboxylic. [ 90 ] different expression of ERR- in different parts of the other,. Bpa were issued under FDAs food additive is not relevant to FDAs determination regarding whether certain... States government,: the subject of prolonged public and scientific debate of - unsaturated carboxylic acids to resins! Protectchildren bisphenol a epoxy resin chemical formula athletes from injuries question is BPA safe 2014 Feb 4. c ) Doerge DR, Twaddle NC Woodling.

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